Health / Medical Topics

    Rebeccamycin

    Pronunciation

    Definition 1

    A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antineoplastic antibiotics. (NCI Dictionary)

    Definition 2

    An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI Thesaurus)




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