Health / Medical Topics

    Geldanamycin Analogue

    Definition 1

    An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. (NCI Thesaurus)

    Definition 2

    An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins. (NCI Dictionary)




    YOU MAY ALSO LIKE

    An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins.
    A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat…
    A gel used to lessen pain from mouth sores caused by chemotherapy or radiation therapy, oral surgery, braces, or disease. Gelclair is…
    An SDS-PAGE based procedure used to identify matrix metalloproteinases.
    A tablet covered with a layer of gelatin.
    A capsule covered with a thin layer of gelatin.

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact